is there any cure for androgenetic alopecia?

Published: 29th March 2010
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Androgenic alopecia
Alopecia is a genetically in which there is a progressive miniaturization of scalp hair thanks to the action of 5-alpha-dihydro-testosterone on the follicular target organ susceptible people.
The androgenic alopecia is the most typical reason for baldness both in men and in the girl. Inherited a polygenic pattern and is produced by the action of androgens in genetically happy people.
Testosterone passes dihydro-testosterone by the action of 5-alpha-reductase. The accumulation of 5-alpha-dihydro-testosterone holds back the metabolism of the follicles. Induction of terminal villous hair only occurs on the scalp in the frontoparietal area and zenith.
The association of fat and balding is common, as is also the sebaceous gland androgen-dependent, it does not imply that the seborrhea is caused alopecia.
the process can begin anytime after adolesence. In the male starts with a delay of hairline fronto-parietal ( giving rise to supposed tickets ). Subsequently has effects on the biparietal and zenith area ( hair in crown or tonsure ) soon after and dependent on the genetic influence is clear delayed hairline and fronto-parietal balding, always respecting the lateral and posterior the scalp.
In girls the pattern is more diffuse, respecting the hairline hair. Frequently increase after menopause, the loss of estrogen protection, but isn't total, the diameter of hair is starting to become thinner and shorter and apigmentados, permitting the scalp.
If a girl is the unexpected onset alopecia, or male pattern continues, accompanied by other manifestations of hyperandrogenism ( hirsutism, acne, changes in the voice ... ) we think of a virilizing disorder and even in androgen-producing growth ( adrenal or ovarian growth ).
Treatment. Lately there has two FDA-approved drugs : Minoxidil and Finasteride. In girls Minoxidil can be used, but not Finasteride
Ideal applicant : male, between eighteen and 60 who starts to notice the appearance of thinner hair at fronto-temporal and / or vertex. It's not efficacious in utterly bald, to observe results requires a 6-12 month period of continuous treatment and may be maintained indefinitely.
Minoxidil. In solution between 2 and five percent, applied one ml every 12 hours and spread with fingers. Should be applied to the hair fully dry. Different studies suggest that minoxidil is more effective than 5% to two percent concentration, and the latter more effective than fake pill in men. In women there's no difference between the numerous concentrations.
side effects : irritation of the scalp, can cause contact rash. Have also been cases of hypertrichosis ( more common in girls being 3-5% in superciliary area and cheeks ). When applied two times a day does not hurt blood pressure or heart beat rate. It is contraindicated in pregnancy and lactation and in patients with heart issues.
Finasteride. It's a competitive inhibitor of 5-alpha-reductase type 2 enzyme responsible for DHT production from testosterone in the follicles of the fronto-temporal area and zenith of the scalp.
For years has been used in the treatment of benign prostatic hypertrophy. The treating of male androgenic alopecia with finasteride 1 mg, was given approval by the FDA in 1997. It's not efficacious in men over 60 years ( since the activity of 5-alpha-reductase is not so high as in the young ). The oral Finasteride is contraindicated in women.
Hormone treatments. In the female hormone treatments have been used as oral antiandrogens with excellent results. Type are used antiandrogens cyproterone acetate mixed with ethinyl estradiol ( Diane 35 ) or alone ( Androcur )
Spironolactone, which is a puny competitive inhibitor of androgen binding to its receptor and reduces the synthesis of testosterone, has some efficiency in the handling of hirsutism, androgenetic alopecia and female adrenal origin.
Surgery. Now being conducted on the autotransplantation of hair, consolidated and highly effective treatment. Its main disadvantage is that by missing the bordering hair, perform one or two corrections. In girls, being more diffuse baldness is tougher to autotransplantation, the giver occipital area has less hair than in men.
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